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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE4C
All Species:
10.91
Human Site:
S249
Identified Species:
30
UniProt:
Q08493
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q08493
NP_000914.2
712
79902
S249
N
R
E
L
T
H
L
S
E
T
S
R
S
G
N
Chimpanzee
Pan troglodytes
XP_001138439
809
91104
S323
L
T
H
L
S
E
M
S
R
S
G
N
Q
V
S
Rhesus Macaque
Macaca mulatta
XP_001091815
725
82653
S256
H
L
S
E
M
S
R
S
G
N
Q
V
S
E
Y
Dog
Lupus familis
XP_852383
903
99971
S427
N
R
E
L
T
H
L
S
E
T
S
R
S
G
N
Cat
Felis silvestris
Mouse
Mus musculus
Q3UEI1
686
76072
L243
S
N
K
F
K
R
M
L
N
R
E
L
S
Y
L
Rat
Rattus norvegicus
P14270
803
90534
S318
L
T
H
L
S
E
M
S
R
S
G
N
Q
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695374
745
84839
R235
T
H
L
S
E
M
S
R
S
G
N
Q
V
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4S9
983
107322
L506
D
K
Q
Q
E
F
D
L
P
S
L
R
V
E
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22000
674
75370
T230
D
Q
L
E
T
I
Q
T
H
R
S
V
S
E
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
62.9
63.8
68.4
N.A.
70.9
63.5
N.A.
N.A.
N.A.
N.A.
65.7
N.A.
41.9
N.A.
46.3
N.A.
Protein Similarity:
100
73.5
75.1
71.5
N.A.
77.9
73.7
N.A.
N.A.
N.A.
N.A.
76.9
N.A.
53.5
N.A.
61.5
N.A.
P-Site Identity:
100
13.3
13.3
100
N.A.
6.6
13.3
N.A.
N.A.
N.A.
N.A.
0
N.A.
6.6
N.A.
20
N.A.
P-Site Similarity:
100
40
20
100
N.A.
26.6
40
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
40
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
23
0
0
0
0
0
12
0
0
0
0
0
0
0
12
% D
% Glu:
0
0
23
23
23
23
0
0
23
0
12
0
0
34
12
% E
% Phe:
0
0
0
12
0
12
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
12
12
23
0
0
23
0
% G
% His:
12
12
23
0
0
23
0
0
12
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
12
12
0
12
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
23
12
23
45
0
0
23
23
0
0
12
12
0
0
12
% L
% Met:
0
0
0
0
12
12
34
0
0
0
0
0
0
0
12
% M
% Asn:
23
12
0
0
0
0
0
0
12
12
12
23
0
0
23
% N
% Pro:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% P
% Gln:
0
12
12
12
0
0
12
0
0
0
12
12
23
0
0
% Q
% Arg:
0
23
0
0
0
12
12
12
23
23
0
34
0
0
0
% R
% Ser:
12
0
12
12
23
12
12
56
12
34
34
0
56
12
23
% S
% Thr:
12
23
0
0
34
0
0
12
0
23
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
23
23
23
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _